Clinical Outcomes of Grade 3 Giant Cell Tumor


The giant cell tumor of bone (GCTB) was described by Cooper and Travers in 1818. It is considered a locally aggressive benign bone tumor with tendency for high recurrence. GCTB represents approximately 5-10% of all primary bone tumors. It typically occurs in 30-40 years of age and is slightly more common in female, also is higher incidence rate in Southeast Asia than Western. The most common GCTB is involved in the epiphyseal regions of long bones, particularly the distal femur and the proximal tibia. Primary malignant turn and distant lung metastasis are about 1% and 3% in GCTB patients, respectively.

The principal symptoms are pain and swelling which are caused by cortical bone destruction and tumor expansion. Addition, joint effusion and limited range of motion are also possible. Pathological fracture shows aggressive progression of disease. The definitive diagnosis is confirmed by histological method. This benign tumor has characteristic multinucleated osteoclast-type giant cells.

There is still not a consensus in surgical treatment of grade 3 GCTB between a wide excision and an extended intralesional excision which it is all about balance between eliminating the tumor and preserving the extremity’s function. This study assesses the functional and oncological outcomes grade 3 GCTB with an extended intralesional curettage combined with adjuvant therapies comprising high-speed burring and bone cementation, instead of a wide excision, to better avoid limb salvage surgery with endoprosthetic reconstruction.

The Journal of Orthopedic Oncology offers information in all aspects of primary, malignant tumors. Osteosarcoma, Ewing's sarcoma, chondrosarcoma, chordoma, and soft tissue sarcomas etc., it also deals with diagnostic methods, therapeutic approaches, clinical, laboratory research and reconstructive techniques.

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Journal of Orthopedic Oncology

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